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논문분류	춘계학술대회 초록집
제목	The Protective Effects of Apelin on Contrast-Induced Nephropathy
저자	JAE SEOK KIM, Hanwul Shin, Miryung Kim, Jun Young Lee, Minseob Eom, Jae Won Yang, Seung Ok Choi, Byoung Geun Han
출판정보	2020; 2020(1):
키워드	Contrast \| Nephropathy \| Apelin
초록	Contrast-induced nephropathy (CIN) is a well-known type of acute kidney injury, while there are no effective methods to prevent CIN except for administration of saline yet. Apelin is an endogenous peptide with vasodilatory and cardiostimulatory effects elevating systemic and renal circulation. Thus, we aim to investigate the protective role of apelin on CIN in the study. Total of twenty-two Sprague-Dawley rats were used in the study. The rats were divided into Vehicle (V, n=4), Apelin (A, n=4), Contrast (C, n=7), and Apelin-Contrast (AC, n=7) groups. All groups were given 50 mg/kg of gentamicin intravenously from day 1 (D1) to D6 for inducing CIN. Total 300 microgram/kg of apelin subcutaneously and 1.8 g Id/kg of contrast (Iohexol, OmnipaqueTM) intravenously were given according to each group on D7. We collected blood and 24-hour urine samples on D0 and D9 which is the time of 48 hours after contrast administration. The results showed that serum creatinine (Cr) increased significantly only in C group (1.59 +/- 0.75 to 2.28 +/- 1.32 mg/dL, p=0.044), while did not in other groups including AC group. The C group also showed a significantly increased urinary excretion of Cr suggesting renal tubular damage. The other parameters including urinary volume and creatinine clearance did not show the significant differences. Based on the results of serum Cr in the study, we suggest that apelin could prevent CIN. But, the results are insufficient to support the protective role of apelin on CIN, and thus we need more data through analysis of kidney tissues.
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