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논문분류	춘계학술대회 초록집
제목	Alhagi maurorum Leaf Extract restricts demethylation - convinced kidney injury in rats through inflection of extirpative pressure and histopathological changes
저자	Nitin Kumar, Heera Lal Sharma
출판정보	2020; 2020(1):
키워드	Demethylation \| nephrotoxicity \| nitrariaceae \| triazole fungicides
초록	The present study elucidates the prospective protective effect of A. maurorum Leaf aqueous extract used for demethylation, a triazole fungicide beside nephrotoxicity induced by, in the kidney of the rats. Adult Wistar rats were exposed either to demethylation (67 mg/kg body weight), or to A. maurorum Leaf extract (300 mg/kg body weight) or to their consolidation. demethylation was execute by intra-peritoneal injection each 2 days from day 7 until day 15, the forfeit day, although A. maurorum Leaf extract was execute every day by gavage during 15 days. Oxidative pressure parameters, histopathological examination and kidney biomarkers were determined. A. maurorum Leaf extract execute to demethylation treated rats decreased kidney levels of protein carbonyls (PCOs, −11%), malondialdehyde (−10%), hydrogen peroxide (−12%), and advanced oxidation protein products (AOPP, −16%); antioxidant enzyme activities: superoxide dismutase (−8%) and glutathione peroxidase (GPx, −14%), catalase (−13%), and the levels of non-enzymatic antioxidants: metallothionein (−12%) and non-protein thiols (−9%), glutathione (−7%). Moreover, this leaf extract prohibited biomarker changes by reducing plasma levels of urea, uric acid, creatinine, and LDH and ever-increasing those of GGT and ALP. demethylation (glomeruli fragmentation of Histopathological alterations induced, Bowman’s space enlargement, tubular epithelial cells necrosis and infiltration of inflammatory leucocytes) were attenuated following A. maurorum. Our outcome indicated that A. maurorum Leaf extract had protective effects beside demethylation -induced kidney injury, which could be attributed to its phenolic compounds.
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