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논문분류	춘계학술대회 초록집
제목	Effect of Pentoxifylline on Contrast-induced Nephropathy: A Systematic Review
저자	Shinta Retno Wulandari, Asticha Erlianing Sari
출판정보	2020; 2020(1):
키워드	Pentoxifylline \| Contrast-Induced Nephropathy \| Contrast media \| Angioplasty
초록	Contrast media that was used in diagnostic and interventional procedures provides high risk complication such as Contrast-Induced nephropathy (CIN). Pentoxifylline (PTX), a methylxanthine derivative with multiple hematologic properties, has some anti-inflammatory properties, and there is evidence that PTX also reduces nitric oxide (NO) deterioration. This systematic review evaluates the effect of pentoxifylline on contrast-induced nephropathy. We conducted a systematic review of all studies published between 2010 – 2020, on outcome of pentoxifylline on contrast induced nephropathy. Through a comprehensive search on PubMed and Cochrane Library. We identified two eligible studies. Risk of bias analysis was performed using the Cochrane Risk of Bias Tool. 485 patients were included in our systematic review. 237 patients were treated with pentoxifylline (PTX) (400 mg three times a day on the day of the coronary angioplasty and the day after) and 248 patients were treated with normal saline (1–1.5 cc/kg from 6 h before to 6 h after coronary angioplasty). Serum creatinine was measured 24 h prior to the procedure and 48 h thereafter. The primary endpoint was occurrence of CIN defined as 25 % rise in serum creatinine 48 h after the procedure. CIN occurred in (10.48%) patients in the control group and in 18 (7.59%) patients in the study group. Both studies found the difference between 2 groups were not statistically significant. Pentoxifylline could be recommended for Contrast-Induced nephropathy (CIN) prevention in patients without renal impairment undergoing angioplasty, although no statistically significant protective effect of Pentoxifylline was documented. Trials in patients with renal impairment are needed to study the role of Pentoxifylline further.
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