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논문분류	춘계학술대회 초록집
제목	Retinal Nonperfusion Area on Ultra-widefield Angiography as a Predictor for Renal Function in Proliferative Diabetic Retinopathy
저자	Kyung Min Kang, Myung A Ha, Ho Cheol Song, Anna Lee, Jae Hyun Park, Jiwon Baek, Ji Won Min
출판정보	2020; 2020(1):
키워드	Diabetic kidney disease \| Diabetic retinopathy \| Renal function
초록	To assess the relationship between retinal vascular abnormalities on ultra-widefield fluorescein angiography (UWFA) and renal function in diabetic chronic kidney disease (DM CKD) patients with proliferative diabetic retinopathy (PDR). UWFA was performed in 271 eyes (of 139 patients) of patients with type 2 DM, DM CKD and treatment naïve PDR. Serum creatinine level, eGFR, urine A/C ratio, and urine P/C ratio were used as parameters for renal function. On UWFA, retinal capillary nonperfusion area (NPA) was measured in automated manner. The correlation between NPA, NVA, and renal function was analyzed. The mean duration of DM CKD patients with PDR was 12.54 ± 9.05 years (range 1 – 40). The mean serum creatinine level, eGFR, urine A/C ratio, and urine P/C ratio was 1.54 ± 2.21 mg/dl, 73.05 ± 35.57 ml/min/1.73m2, 901.86 ± 2639.61 mg/g, and 2.04 ± 3.05, respectively. A significant correlation was found between NPA and serum creatinine, eGFR, urine A/C ratio, and urine P/C ratio (r = 0.413, -0.490, 0.343, 0.452, respectively; all P ≤ 0.002,). NPA of the macular area also correlated with each renal function parameter (r = 0.229, -0.506, 0.320, and 0.338, respectively; all P ≤ 0.038). Larger nonperfusion area was associated with worse renal function. Retinal NPA on UWFA can be used to predict renal function in DM CKD patients with PDR.
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