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논문분류	춘계학술대회 초록집
제목	Foot process effacement induced by mesangial proliferation leads to proteinuria in IgA neprhopathy
저자	Jin Young Yu, Ji-Hye Lee, Nam-Jun Cho, Eun Young Lee, Hyo-Wook Gil, Samel Park
출판정보	2020; 2020(1):
키워드	glomerulonephritis \| IgA nephropathy \| podocytes \| proteinuria
초록	Proteinuria is a significant risk factor of the progression of IgA nephropathy (IgAN), and has a positive correlation with the severity of foot process effacement (FPE). We evaluated the relation between FPE, proteinuria, and histologic characteristics, including the Oxford classification. Patients who performed a renal biopsy and were diagnosed with IgAN at a single center were retrospectively reviewed. Young patients with age under 18 years old and the possibility of secondary causes were excluded. Then, we evaluated the association between the degree of proteinuria, the severity of FPE, and histologic characteristics, including the Oxford classification and other immunofluorescence stains. total of 805 cases of the renal biopsy performed at our institution, 327 patients were diagnosed with IgAN. Among them, 57 patients were excluded. The severity of FPE had an impact on the degree of proteinuria. Notably, the group with FPE ≥ 90% had more than about 2 g/day of urine protein compared to those with FPE < 10%. Among the histologic characteristics, M1 score and immune deposition of IgG affected the severity of FPE [hazard ratios (95% CI), 1.93 (1.15 – 3.24), and 3.86 (1.78 – 8.36), respectively] (Table 1). The severity of FPE had an impact on the degree of proteinuria, and the severity of FPE was associated with the pathogenesis of IgA nephropathy.
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