대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Urinary cell-free DNA as a biomarker in immunoglobulin A nephropathy
저자	Jung Nam An, Joonho Jang, Jin Hyuk Kim, Do Hyoung Kim, Jeonghwan Lee, Yun Kyu Oh, Chun Soo Lim, Jung Pyo Lee
출판정보	2020; 2020(1):
키워드	cell-free DNA \| urine sample \| immunoglobulin A nephropathy \| biomarker
초록	Cell-free DNA (cfDNA), measured in blood, has been reported to be of clinical significance in many immune and kidney diseases. However, urinary cfDNA has not been studied much, especially in kidney disease. We analyzed urinary cfDNA in immunoglobulin A nephropathy (IgAN). We measured cfDNA in urine samples collected at the time of diagnosis of 98 IgAN and analyzed the correlation between these values and various clinical parameters and kidney pathologic findings. Linear regression analysis showed a significant negative correlation with serum albumin (β = -0.246, P = 0.015) and a significant positive correlation with total cholesterol level (β = 0.247, P = 0.014). There was no correlation between proteinuria, serum creatinine (sCr) and GFR at diagnosis, and urinary cfDNA. However, when cfDNA was divided by median value and the renal function was compared between the two groups; the higher cfDNA group showed lower sCr (1.21 mg/dL vs. 0.98 mg/dL, P = 0.031) and higher GFR (53.3 mL/min/1.73 m2 vs. 86.7 mL/min/1.73 m2, P = 0.014), that is, better renal function. Among the biopsy findings, cfDNA was lower in patients with interstitial fibrosis/tubular atrophy (P = 0.019). In patients with fibrointimal thickening of the vessel (P = 0.032) or hyaline arteriosclerosis (P = 0.028), cfDNA tended to be lower. There was no significant correlation with other pathological findings, however. Urinary cfDNA levels were significantly correlated with various clinical markers and biopsy findings in patients with IgAN. Higher cfDNA levels were measured in patients with better renal function and less tissue injury. Further analysis will be needed to predict treatment response or to predict long-term kidney prognosis.
원문(PDF)	PDF 원문보기

목록

위로가기