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논문분류	춘계학술대회 초록집
제목	Bariatric Surgery Alters Fibroblast Growth Factor 21 and Angiotensin-converting Enzyme 2/ Angiotensin (1-7) Axis in Patients with Morbid Obesity
저자	Byung Chul Yu, Hyoungnae Kim, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Hyeong Kyu Park, Moo Yong Park, Sang Hyun Kim, Soon Hyo Kwon
출판정보	2020; 2020(1):
키워드	Obesity \| Bariatric surgery \| Fibroblast growth factor 21 \| Angiotensin-converting enzyme 2 \| Angiotensin 1-7
초록	Recent studies showed that the fibroblast growth factor 21 (FGF-21) and angiotensin-converting enzyme 2 (ACE2)/Angiotensin 1-7 (Ang 1-7)/Mas axis of the renin-angiotensin system counteract to the negative role of Ang II in various disease. In this study, we examined FGF-21, ACE2, Ang (1-7), and Ang II in obesity and its change after bariatric surgery. We prospectively enrolled obese patient (n=12) who performed bariatric surgery and age-sex matched healthy volunteers (HVs) (n=12 each). Serum FGF-21, Ang II, ACE2, and Ang (1-7) levels were measured by enzyme-linked immunosorbent assay kits. We measured also FGF-21, Ang II, ACE2, and Ang (1-7) 6 months after bariatric surgery in obese patients. FGF-21, Ang II and ACE2 levels were significantly higher in obese patients compared with HVs (p = 0.034, < 0.001, and p = 0.020, respectively) and decreased after bariatric surgery (p = 0.002, 0.005, and 0.020, respectively) (Figure 1). There was no significant difference in Ang (1-7) levels between obese patients and HVs (p = 0.887). Weight reduction surgery did not change Ang (1-7) levels in patients with obesity (p = 0.480). However, changes in Ang (1-7) levels were positively correlated with changes in body mass index (BMI) after surgery (R2 = 0.580, p = 0.048) (Figure 2). FGF-21 and ACE2 were upregulated in patients with obesity and they are reduced after bariatric surgery. A decrease in BMI after bariatric surgery was associated with the decrease in Ang (1-7).
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