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논문분류	춘계학술대회 초록집
제목	Association of Pulse Pressure with Renal Function in Subjects With Diabetes, Prediabetes, or Normal Glucose Tolerance
저자	Jiae Yang, Soowan Kim, Hongsang Choi, Changseong Kim, Eunhui Bae, Seongkwon Ma
출판정보	2020; 2020(1):
키워드	arterial stiffness \| pulse pressure \| DM \| eGFR
초록	Arterial stiffness is a risk factor for cardiovascular disease in patients with chronic kidney disease (CKD). Recently, pulse pressure (PP), a marker of arterial stiffness has been suggested as a predictor of adverse renal outcome in CKD. However, the association between PP and renal function decline in diabetes and pre-diabetes has not yet been determined. The present study was aimed to investigate the association between PP and estimated glomerular filtration rate (eGFR) in patients with diabetes, pre-diabetes and normal glucose tolerance. To compare the impact of PP on renal function, 23,849 subjects from Korea National Health and Nutrition Examination Survey (2015 to 2018) were categorized by PP as follows: group 1, < 43 mmHg; group 2, 43-48 mmHg; group 3, 49-54 mmHg; group 4, 55-62 mmHg; group 5, ≥ 63 mmHg. We classified diabetes, pre-diabetes and normal glucose tolerance groups according to American diabetes association guidelines, and calculated the eGFR using the CKD-EPI equation. The data were analyzed with the complex samples general linear model. In diabetes, incidence of proteinuria increased with increasing PP, but not in pre-diabetes and normal glucose tolerance. Pre-diabetes showed reduced eGFR in only group 5 compared with group 1. However, eGFR of diabetic patients was significantly lower in group 2-5 compared with group 1. These findings suggest that diabetes showed a significant decrease of eGFR even at mild degree of PP than the pre-diabetes and normal glucose tolerance. Thus, the change of PP should be carefully monitored in diabetes.
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