대한신장학회

논문분류	춘계학술대회 초록집
제목	Predictors for renal outcome in living kidney donors : From data of Korean Organ Transplantation Registry
저자	Yunmi Kim, Min Ji Kim, Jung Jun Lee, Jung Pyo Lee, Jaeseok Yang, Curie Ahn, Chanil Park, Taehee Kim, Sun Woo Kang, Yeong Hoon Kim
출판정보	2020; 2020(1):
키워드	Living kidney donor \| Transplantation \| Chronic kidney disease \| Glomerular filtration rate
초록	The safety of donors is one of the most important issues in living donor kidney transplantation. We investigated predictors of renal outcome in living kidney donors. We analyzed data of kidney donors registered to a nationwide prospective registry, the Korean Organ Transplantation RegistrY, from May 2014 to December 2016. Among a total of 1,497 living kidney donors, 456 donors were followed up until 2 years with serum creatinine measurement after nephrectomy. We analyzed factors related to renal outcome of donors. Chronic kidney disease (CKD) was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 or spot urine protein-to-creatinine ratio ≥ 150mg/g or spot urine microalbumin-to-creatinine ratio ≥ 30mg/g or 24-hour urine protein ≥ 150mg. At 2 years after kidney donation, CKD developed in 99 (21.7%) donors. Donors who had incident CKD were older (50.1±10.8 vs. 42.5±11.7 years-old), and more likely to have hypertension (12.1% vs. 5.0%), higher uric acid (5.4±1.5 vs. 4.9±1.4 mg/dL), higher glucose level (102±18 vs. 97±12 mg/dL), lower predonation eGFR (88±13 vs. 106±13 mL/min/1.73m2) than subjects who did not develop CKD. The eGFR decreased 0.4±3.6 ml/min/1.73m2 per year since nephrectomy in incident CKD group, while it increased 2.2±1.7 ml/min/1.73m2 per year in non-CKD group (p=0.008). In multivariate logistic regression analysis, higher systolic blood pressure was associated with higher risk of CKD (OR, 1.322 per 10 mmHg increment; 95% CI, 1.036-1.686; p=0.025), and higher predonation eGFR (OR, 0.906 per 1 ml/min/1.73m2 increment; 95% CI, 0.876-0.936; p<0.001) and higher ratio of eGFR at discharge to predonation eGFR (OR, 0.603,1 per 0.1 increment; 95% CI, 0.428-0.849; p=0.004) were related to lower risk of CKD. Higher blood pressure was related to higher risk of CKD in kidney donors. Higher predonation eGFR and less decline of eGFR after nephrectomy were predictors for long-term preservation of renal function.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정