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논문분류	춘계학술대회 초록집
제목	Usefulness of Pre- and Post- Transplant BK Virus-Specific ELISPOT Assay for Predicting the outcome of BK virus infection in Kidney Transplant Recipients
저자	Eun Jeong Ko, Hyunjoo Bae, Ki Hyun Park, Cheol Whee Park, Chul Woo Yang, Byung Ha Chung, Eun-Jee Oh
출판정보	2020; 2020(1):
키워드	polyomavirus BK \| kidney transplantation \| viremia \| BK virus-associated nephropathy \| ELISPOT
초록	To investigate if BK virus (BKV)-specific T-cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay at pre – and post-transplantation can predict the outcome of BK virus infection in kidney transplant recipients (KTRs). We included 60 KTRs with BK viremia and checked BKV ELISPOT assay at pre and post-transplant 1month (M), 3M, and the time of BKV viremia detected. All participants were divided into Persistent-viremia group(< three months) and Cleared-viremia group (> three months) according to sustained duration of BKV infection. We compared pre- and post-KT BKV-ELISPOT results against five BKV peptide mixes (LT, St, VP1-3), and Fluorescence-activated cell sorting of immune cell (FACS) results. We included 60 KTRs with BK viremia and checked BKV ELISPOT assay at pre and post-transplant 1month (M), 3M, and the time of BKV viremia detected. All participants were divided into Persistent-viremia group(< three months) and Cleared-viremia group (> three months) according to sustained duration of BKV infection. We compared pre- and post-KT BKV-ELISPOT results against five BKV peptide mixes (LT, St, VP1-3), and Fluorescence-activated cell sorting of immune cell (FACS) results. Pre- and Post-transplant BKV-ELISPOT assay may be effective in predicting clinical outcomes of BKV infection in terms of clearance of BK virus and development of BKVN.
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